Drugs that increase signaling of Sonic Hedgehog (Shh) can help suppress the involuntary movements associated with dopamine replacement therapy for those with Parkinson’s disease.

Schizophrenia itself is associated with loss of excitation, but hallucinations and other symptoms of the disorder are caused by a loss of synaptic inhibition.

Two new intranasal drugs slow inflammation and stop the spread of alpha-synuclein in mouse models of Parkinson’s disease. The drug also improved gait and balance in the animals. If the results are able to be replicated in humans, researchers say the dr…

Researchers discovered people with a specific variant of the oxytocin receptor gene OXTR follow more people on Instagram. However, there no evidence was found to suggest gene-environment interactions influence online sociability.

Researchers identified specific receptors for acetylcholine that reroute information flow through memory circuits in the hippocampus. The findings could have implications for the development of drugs to help enhance or protect memory from diseases asso…

A new study finds dopamine increases responses to stressful stimuli, not just pleasurable ones. The findings could have implications for the treatment of mental health disorders and addiction.

A newly identified gene therapy pathway has the potential to protect us against dementia and cancer, researchers report.

Stem cell study reveals astrocytes carrying the Alzheimer’s associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta productio…

Amyloid-beta proteins created in the liver are carried in the blood by lipoproteins to the brain. This results in neurodegeneration, brain atrophy, and inflammation, which are common features of Alzheimer’s disease.

A new deep learning algorithm identified key features underlying success in the art world. Researchers report a link between exploration and exploitation was associated with artistic success.

Researchers discovered mutations of the OPTN gene resulted in increased herpesvirus 1 growth in the brains of mice, leading to the death of local neurons. This resulted in accelerated neurodegeneration. OPTN deficiency was also associated with impairme…

Those who exercise regularly may lower their risk of developing anxiety by 60%, researchers report.

Older adults who frequently connect with friends and others in social situations perform better on cognitive function tests than those who are not so social.

A new study on aging reveals a surprising discovery about the connection between protein shape and mitochondrial health.

A new, open access repository incorporates frequently asked questions and answers by genomics researchers to provide a better general understanding of what their studies do, and do not show.

Study reports a significant number of people with Parkinson’s disease have precise deficits when learning from instructions. Researchers say the problems are associated with differences in brain function.

Novel AI technology allows researchers to understand which brain regions directly interact with each other, which helps guide the placement of electrodes for DBS to treat neurological diseases.

A new statistical model lays groundwork for understanding how ketamine induces an anesthetic response, steps to monitor unconscious patients, and provides new information about brain activity while unconscious.

Study reveals individual differences in how we perceive and imagine visual images we have seen.

The function of the opioid system is connected to eating triggered by external stimuli. The findings could lead to the development of new therapies that target the opioid system to reduce obesity.